Programme

Registration

Lunch

Session 1: Autophagy

Chairs: Roberto Sitia & Carmine Settembre

Laura Cinque (Naples)

FGF18 regulates bone size through macroautophagy

Katia Cortese (Genoa)

Heat shock protein 90 inhibition in ErbB2-overexpressing breast cancer cells causes ErbB2 proteolytic fragmentation and lysosomal degradation simultaneously with alterations of endocytic recycling and suppression of autophagy

Riccardo Cristofani (Milan)

Inhibition of dynein ATPase activity reduces high molecular weight forms of misfolded proteins involved in motoneuron diseases

Maurizio Renna (Cambridge, UK)

IGF-1R signalling and regulation of autophagosome biogenesis: novel findings against an old paradigm

Thomas Vaccari (Milan)

Multiple functions of the SNARE protein Snap29 in autophagy, endocytic and exocytic trafficking during epithelial formation in Drosophila

Maria Giovanna De Leo (Naples)

Defining the role of the PtdIns(4,5)P2 5-phosphatase OCRL in the late endosomal compartment and autophagy

Coffee break

Session 2: Endocytic Pathway

Chairs: Simona Paladino & Cecilia Bucci

Leopoldo Staiano (Naples)

Looking for correctors of Lowe Syndrome: a High Content Screening (HCS) approach

Lorena Urbanelli (Perugia)

MicroRNAs regulate lysosomal system by targeting MPRs and Adaptor Protein complex 1 subunits

Alessia Castagnino (Genoa)

Role of ErbB1 in ErbB2 membrane redistribution induced by Trastuzumab treatment in SK-BR-3 cells

Plenary Lecture

Anne Spang (Basel, Switzerland)

Regulation of transport through the endocytic pathway

General discussion and election of next vice-chair

Dinner

Poster Session

Session 3: Endoplasmic Reticulum

Chairs: Sara Colombo & Stefano Bonatti

Tiziana Anelli (Milan)

A dynamic study of protein condensation in the secretory pathway

Paola Genevini (Milan)

ER-derived inclusions generated by ALS-linked mutant VAPB are cleared by cells and do not interfere with proteostasis or protein transport

Sara Sannino (Milan)

Regulation of protein quality control at the ER-Golgi interface: role of conserved histidines in dictating ERp44 localization and function

Mariano Stornaiuolo (Naples)

Rescue of folding defects, modulation of receptor activity and anti-tumoral potential of the first organic molecules addressing Frizzled4

Alberto Danieli (Ceriano Laghetto, MB)

A novel approach for correlative light and electron microscopy

Laura Oliva (Milan)

Inherent cellular stress and exquisite proteasome sensitivity in amyloidogenic plasma cells

Coffee break

Session 4: Golgi

Chairs: Paolo Remondelli & Nica Borgese

Antonino Colanzi (Naples)

Golgi complex fragmentation in G2/M transition: an organelle-based cell-cycle checkpoint

Mafalda Concilli (Naples)

Identification and functional study of Wilson disease protein interactors

Carmen Valente (Naples)

Molecular mechanisms of post-Golgi tubular carrier formation

Simona Paladino (Naples)

Cholesterol-dependent sorting in the Golgi regulates the supramolecular organization and activity of GPI-anchored proteins at the apical membrane of polarized epithelial cells

Alexandre Mironov (Milan)

Experimental comparison of prediction power of different models of intra-Golgi transport suggests in favour of the kiss-and-run mechanism

Lunch and Departures